Tumor anti-initiating activity of some novel 3, 4-dihydropyrimidinones

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Tumor anti-initiating activity of some novel 3,4-dihydropyrimidinones.

Halting the tumor initiation process by targeting the inhibition of the carcinogens metabolic activators (CYP), the induction of the carcinogen detoxification enzymes (glutathione-S-transferases, GSTs), and the induction of antioxidant activity is an effective strategy. Since several dihydropyrimidine derivatives (Biginelli compounds) are therapeutically active, the present study aimed to synth...

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ژورنال

عنوان ژورنال: Pharmacological Reports

سال: 2009

ISSN: 1734-1140

DOI: 10.1016/s1734-1140(09)70178-1